Commercial building heating, ventilating, and air conditioning (HVAC) systems are designed primarily to maintain a reasonable level of thermal comfort while limiting first costs and energy consumption. However, research conducted predominately within the last decade suggests that commercial building HVAC significantly influences human outcomes other than thermal comfort, including the health, satisfaction, and work performance of the building's occupants. This presentation will review the relationships of these outcomes with HVAC system type, filtration system efficiency, indoor air temperature, and outside air ventilation rate. LBNL's research contributions will be emphasized, including cross-sectional and experimental field studies and critical reviews of the state of knowledge. The presentation will conclude with a brief discussion of the changes to commercial HVAC operation and design that may be implemented to improve worker health and performance.